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Játtað í: 2020 Granskingarøki: Heilsa Verkætlanarslag: Verkætlan Verkætlanarheiti: Vøddaglykogen og vøddavirkni undir hørðum intervalarbeiði við denti á kaliumregulering. Játtanarnummar: 0349 Verkætlanarleiðari: Magni Mohr Stovnur/virki: Deildini fyri Heilsu og Sjúkrarøkt, Fróðskaparsetrið Aðrir luttakarar: Jeppe Foged Vigh-Larsen, Kristian Overgaard, Niels Ørtenblad, Pál Weihe, Ole Emil Andersen, Hallur Thorssteinsson Verkætlanarskeið: Original: 01.01.2021 - 31.12.2021 Final:01.01.2021 - 31.07.2022 Samlaður kostnaður: kr. 840.000 Stuðul úr Granskingargrunninum: kr. 200.000 Verkætlanarlýsing: Original: Muscle glycogen is stored in different compartments in skeletal muscle andi s a major fuel source during exercise. Accordingly, a close temporal relationship has been demonstrated between muscle glycogen content and exercise tolerance during both prolonged and high intersity intermittet exercise. Muscle glycogen stores are therefore important for our ability to sustain a given exercise intensity, which is of relevancy during work tasks, exercise and possibly even daily physical activities. The effert of low muscle glycogen on exercise tolerence is likely to be related to several mechanisms. Thus, except the role as an important energy substrate, resulting in a reduced rate of glycolysis in a glycogen depleted state, lowered muscle glycogen content has also been demonstrated to affect muscle excitation-contraction coupling in terms of altered calcium kinetics. In addition, the sodium-potassium pumps which are the main regulators of the muscle excitability and contractility may be adversely influenced by the muscle glycogen depletion due to their preferential use of glycogen as a substrate. In addition, it has been demostrated, that despite whole-muscle glycogen still being above critical leves, specific sub-groups of skeletal muscle fibers and compartments within the muscle cell may be a low glycogen state. Lowered muscle glycogen content may therefore impair muscle function even at moderately reduced levels, which has been suggested in several previous studies. In athletic populations this is crucial for performance, but for the general population this may also have important implications. For example, untrained persons, elderly or certain patients groups, such as type 2 diabetics, may have low initial glycogen concentrations in their muscles due to a low training state and/or an impaired capacity for glucose uptake. For these peaple, exercise is a key element to counteract reductions in cardiovascular – and skeletal muscle health, as well as in the management of type 2 diabetes. However, the iowered initial muscle glycogen stores in these individual already at the onset of exercise may advance fatigue development and reduce their abiliity to tolerate exercise, especially of higher intensities. Therefore, a better understanding of mechanisms related to muscle glycogen and muscle function and fatigability is critical in order to target training, dietary and/or pharmacological interventions. Thus, the aim of the present project is to study the relationship between muscle glycogen content and muscle function, with special emphasis on skeletal muscle potassium regulation. This will be accomplished in a dual project with the use of an exercise protocol and subsequent diet intervention with concomplished measures of muscle glycogen content, muscle function, potassium regulation and exercise tolerence. In addition, an animal model will be applied in order to be able to obtain more direct measures of potential underlying mechanistic regulators of muscle function in association with lowered muscle glycogen content. Final: Verkætlanin er eitt samstarv ímillum Fróðskaparsetrið, Syddansk Universitet og Århus Universitet. Vit hava kannað sambandið ímillum vøddaglykogen og vøddamøði undir intensum arbeiði. Hetta er ein hypotesa fyrst framsett í 1960´árunum, men sum ongantíð er prógva mekanistisk. Vit kann møguligar fysiologiskar mekansikmum, sum via lágt glykogen viðføra kropsliga møði. Vit vísa eitt tætt samband ímillum tømd glykogenlagur í serstøkum økjum í vøddakyknuni og vøddamøði, umframt at vit síggja tekin uppá at broytingar í jónreguleringini í vøddunum kann vera orsøkin til vøddamøði, tá glykogengoymslurnar vera tømdar. Úrslitini eru avgerandi fyri at skilja vøddamøði, sum er av týdningi, tá venjing og kapping í úrvalsítrótti skal leggjast til rættis. Eisini er vitanin týðandi fyri vanlig fólk í samband við kropslig íðkan og kostinntøku. Talan er eisini um grundgransking, sum er umráðandi fyri sjúklingar við metabolskum sjúkum, sum t.d. sukursjúku. Støða: Liðug Avrik: Scientific Articles: Jeppe F Vigh-Larsen, Niels Ørtenblad, Joachim Nielsen, Ole E Andersen, Kristian Overgaard, Magni Mohr (2022). The Role of Muscle Glycogen Content and Localization in High-Intensity Exercise Performance: A Placebo-Controlled Trial. Med Sci Sports Exerc. 2022 Jul 16. doi: 10.1249/MSS.0000000000003002. Online ahead of print. Jeppe F Vigh-Larsen, Niels Ørtenblad, Ole E Andersen, Hallur Thorsteinsson, Thea H Kristiansen, Stine Bilde, Mads S Mikkelsen, Joachim Nielsen, Magni Mohr, Kristian Overgaard (2022). Fibre type and localisation-specific muscle glycogen utilisation during repeated high-intensity intermittent exercise J Physiol. 2022 Aug 28. doi: 10.1113/JP283225. Online ahead of print. Abstract presented at ACSM conference in San Diego, USA, June 2022. All data are anonymized and all tissue samples are discarded. << Back |
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