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Játtað í: 2020 Granskingarøki: Heilsa Verkætlanarslag: Ph.d.-verkætlan Verkætlanarheiti: Tann føroyski knæ-kanningarbólkurin. Ein kanning av etiologi og langtíðar avleiðingum av Trochlear Dysplasi og knæ-skels keiking. Játtanarnummar: 0350 Verkætlanarleiðari: Niclas Højgaard Eysturoy Stovnur/virki: Landssjúkrahúsið Aðrir luttakarar: Kristoffer W. Barfod, Lars Blønd, Hans Christian Husum. Verkætlanarskeið: Planned: 01.08.2021-31.07.2051 Actual: 01.08.2021 – ongoing PhD.-project: 01.05.2023 – 20.06.2025 Samlaður kostnaður: kr. 1.296.692 Stuðul úr Granskingargrunninum: kr. 670.000 Verkætlanarlýsing: Original The Faroese Knee Cohort is a unique project investigating the etiology, risk factors and long term implications of patellar instability (P1) and trochlea dysplasia (TD) – a condition that is more common and more disabling than cruciate ligament injuries. Purpose of the study/project: The overall aim of the study is to investigate etiology and long term implications og P1 and TD and patellar dislocation (PD). The study has a short term and a long term overall objective. 1. In the short term, the objective is to investigate the epidemiology of trochlear dysplasia with special focus on risk factors, familiar association and genetic influence in a nationwide cohort at the Faroes Islands. 2. In the long term the objective is to investigate the influence of trochlear dysplasia on patient reported function, quality of life and development of osteoarthritis over a 30-year span. Background. Femoral Trochlear Dysplasia (TD) is a major predisposing factor for patellar instability. The high incidence of patellar dislocations of 42 per 100.000 person years, typically in young adults, has led to intense research on a world wide scale. However, the etiology of TD has yet to be explained, though, researchers are suspicious of a familiar association, as well as a balanced translocation of chromosomes 15 and 20. Furthermore, patellar instability is a known risk factor for development of osteoarthritis (OA) of the knee – the fourth largest disabling according to the WHO. The Faroese Knee Cohort will permit unique investigations of the development of OA in regards to genetic disposition and other factors over a 30years span. About the project: This is a prospective national cohort stody including the whole Faroese population aged 15-20 years. People will be invited to join the study if they have experienced PD or have P1. They will be screened for TD, a feometrical abnormality in the distal femur where the patella engages, by a true lateral X-ray and a bilateral MRI scan of the knees. In the outpatient clinic, they will undergo a clinical assessment and answer a variety of questionnaires. Lastly, they will draw a blood-sample for later genetic analysis. All data will be stored in a secured database at The National Genetic Biobank in the Faroe Island. The patients will be followed for 30 years with a yearly questionnaire. At 5, 10, 15, 20 and 30 years we plan a clinical follow up and to take an X-ray of the knees to asses OA. Final The Faroese Knee Cohort was established in 2021 as a national cohort study. To date, 46% of all citizens in the Faroe Islands aged 15–19 years have completed the baseline online questionnaire. Furthermore, a subgroup of 100 participants was invited to undergo comprehensive assessments, including conventional radiography, magnetic resonance imaging (MRI), clinical examination, and blood sampling. The data collected during the initial phase of the study have already resulted in three international peer-reviewed publications, including one in the highly regarded journal The American Journal of Sports Medicine. The main findings are as follows: High Prevalence of Patellar Dislocation: The study revealed a 9% lifetime prevalence of patellar dislocation among Faroese adolescents, approximately seven times higher than previously reported in any other population worldwide. High Prevalence of Trochlear Dysplasia: A correspondingly high prevalence of trochlear dysplasia, the most significant anatomical risk factor for patellar dislocation, was also identified, suggesting a unique distribution of predisposing morphological factors in this population. Long-Term Impact on Quality of Life and Function: Adolescents who sustained a patellar dislocation but were treated non-operatively reported significantly reduced quality of life and physical function even several years after the initial injury. These findings underscore the potential severity of patellofemoral instability and support a more individualised and evidence-based approach to clinical decision-making between patient and surgeon. Radiological Measurements Do Not Predict Patient-Reported Outcomes: Contrary to the initial hypothesis, no significant correlation was found between radiological measurements and self-reported health status. This challenges the common assumption that radiographic severity directly reflects subjective symptom burden, highlighting the need for caution when relying solely on imaging findings in clinical assessment and treatment planning. The project is ongoing. Participants continue to receive annual patient-reported outcome measures (PROMs), and radiographic follow-up is scheduled every five years. All data are securely stored and managed using the REDCap database hosted by the National Hospital of the Faroe Islands. Støða: Liðug Avrik: The PhD thesis was successfully defended on June 20, 2025. Thesis title: The Faroese Knee Cohort: An investigation of epidemiology and implications of patellar dislocation and trochlear dysplasia. For results from this project, see PURE << Back |
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