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Year of grant: 2019 Research Area: Heilsa - Sjúkrakassagrunnurin Project type: R&D Project title: Microbiom and Parkinson’s disease Grant number: 3026 Project manager: Maria Skaalum Petersen Institution/company: Deildin fyri Arbeiðs og Almannaheilsu Other participants: Prof. Beate Ritz, Sára Bech, Súsanna Crooks, Pál Weihe, Jan Aasley og Matthew Farrer. Project period: 01.01.2021-30.06.2026 Total budget: kr. 1.576.942 Grant from the FRC in DKK: kr. 851.734 Project description: Original The human microbiome has a major role in uptake and handling of nutrients, medications, and toxins; and is of great immune system relevance. Evidence is mounting that it can affect aspects of neurologic function, brain activity, and behavior via the ‘gut-brain-axis’ and that it plays a role in Parkinson’s disease (PD). PD is a complex and progressive neurodegenerative disease with non-motor symptoms that include gastro-intestinal (GI) features such as constipation and gastro-paresis. Pathologic hallmarks of PD, namely Lewy bodies and α-synuclein aggregates, and inflammation have been found in the gut of PD patients. The role of the gut microbiome in PD is underexplored and no Nordic study has to our knowledge addressed the microbiome influences on PD yet. We will capitalize on the Faroese Parkinson's cohort resources to explore the hypotheses that an altered gut microbiome contributes to the onset of neurodegeneration in PD. We propose to analyze the bacterial gut flora of 50 Faroese PD patients and 100 matched controls (50 household & 50 community controls) using 16S ribosomal RNA to assess microbiome differences between patients vs. controls. Importantly, we will also newly enroll 20 new-onset, medication naïve PD patients and another 40 (20 household and 20 community) controls and collect data on exposures, gut motility indicators in addition to fecal and blood samples. We will follow these drug-naïve PD patients and collect a second stool (and blood) sample one year after they started their PD medications and assess compositional biota differences over time. Our research may contribute to the discovery of potentially novel etiologies and treatment options in PD and neurodegeneration in general. Our research may contribute to the discovery of potentially novel etiologies and treatment options in PD and neurodegeneration in general. Final In this project, we explored whether an altered gut microbiome contributes to neurodegeneration and the onset of Parkinson’s disease (PD). We have recruited 48 patients, 49 control subjects, and 27 household controls. Facel sampels have been analysed and results are pening but are expected to be published early in 2026. Project status: Virkin Project output: See PURE Storage and access rights to collected data Data, both results and biological materinal, is being stored at Department of Research. Access to data can be obtained on collaborative basis and after obtaining the needed permissions. << Back |
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